Resources
One of our drivers behind this project is to improve accessibility of highly dimensional complex data in cardiac research. Here we showcase our range of interactive apps and data exploration tools where you can search for your favourite genes, depict cell type locations, and fuel your own hypotheses.
Fetal Heart Atlas Portal
Our research so far has generated an extensive map of the human fetal heart. Here you can interact with our carefully curated datasets at single-cell and spatial resolutions. You can also access the raw data for your own deeper investigations.
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Semih Bayraktar, James Cranley, Kazumasa Kanemaru, Vincent Knight-Schrijver, Maria Colzani, Hongorzul Davaapil, Jonathan Chuo Min Lee, Krzysztof Polanski, Laura Richardson, Claudia I. Semprich, Rakeshlal Kapuge, Monika Dabrowska, Ilaria Mulas, Shani Perera, Minal Patel, Siew Yen Ho, Xiaoling He, Richard Tyser, Laure Gambardella, Sarah A. Teichmann, Sanjay Sinha
bioRxiv 2024.04.27.591127; doi: https://doi.org/10.1101/2024.04.27.591127
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James Cranley, Kazumasa Kanemaru, Semih Bayraktar, Vincent Knight-Schrijver, Jan Patrick Pett, Krzysztof Polanski, Monika Dabrowska, Ilaria Mulas, Laura Richardson, Claudia I. Semprich, Rakeshlal Kapuge, Shani Perera, Xiaoling He, Siew Yen Ho, Nadav Yayon, Liz Tuck, Kenny Roberts, Jack A. Palmer, Hongorzul Davaapil, Laure Gambardella, Minal Patel, Richard Tyser, Sanjay Sinha, Sarah A. Teichmann
bioRxiv 2024.04.29.591736; doi: https://doi.org/10.1101/2024.04.29.591736
Publications
Fetal Heart CellMatrix
An extension of our Fetal Heart Atlas dataset using R shiny. A summary-level app combining matrix plots and spatial transcriptomics for quick gene exploration across a variety of parameters.
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Semih Bayraktar, James Cranley, Kazumasa Kanemaru, Vincent Knight-Schrijver, Maria Colzani, Hongorzul Davaapil, Jonathan Chuo Min Lee, Krzysztof Polanski, Laura Richardson, Claudia I. Semprich, Rakeshlal Kapuge, Monika Dabrowska, Ilaria Mulas, Shani Perera, Minal Patel, Siew Yen Ho, Xiaoling He, Richard Tyser, Laure Gambardella, Sarah A. Teichmann, Sanjay Sinha
bioRxiv 2024.04.27.591127; doi: https://doi.org/10.1101/2024.04.27.591127
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James Cranley, Kazumasa Kanemaru, Semih Bayraktar, Vincent Knight-Schrijver, Jan Patrick Pett, Krzysztof Polanski, Monika Dabrowska, Ilaria Mulas, Laura Richardson, Claudia I. Semprich, Rakeshlal Kapuge, Shani Perera, Xiaoling He, Siew Yen Ho, Nadav Yayon, Liz Tuck, Kenny Roberts, Jack A. Palmer, Hongorzul Davaapil, Laure Gambardella, Minal Patel, Richard Tyser, Sanjay Sinha, Sarah A. Teichmann
bioRxiv 2024.04.29.591736; doi: https://doi.org/10.1101/2024.04.29.591736
Publications
Adult Heart Atlas
Previous research from the Teichmann laboratory has generated an atlas of the human adult heart. Similar to the Fetal Heart Atlas portal, the adult heart cell atlas has interactive curated data, as well as raw data allowing users to explore the adult heart at high resolution online or offline.
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Monika Litviňuková, Carlos Talavera-López, Henrike Maatz, Daniel Reichart, Catherine L. Worth, Eric L. Lindberg, Masatoshi Kanda, Krzysztof Polanski, Matthias Heinig, Michael Lee, Emily R. Nadelmann, Kenny Roberts, Liz Tuck, Eirini S. Fasouli, Daniel M. DeLaughter, Barbara McDonough, Hiroko Wakimoto, Joshua M. Gorham, Sara Samari, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Giannino Patone, Joseph J. Boyle, Hongbo Zhang, Hao Zhang, Anissa Viveiros, Gavin Y. Oudit, Omer Ali Bayraktar, J. G. Seidman, Christine E. Seidman, Michela Noseda, Norbert Hubner & Sarah A. Teichmann
Nature 588, 466–472 (2020). https://doi.org/10.1038/s41586-020-2797-4
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Kazumasa Kanemaru, James Cranley, Daniele Muraro, Antonio M. A. Miranda, Siew Yen Ho, Anna Wilbrey-Clark, Jan Patrick Pett, Krzysztof Polanski, Laura Richardson, Monika Litvinukova, Natsuhiko Kumasaka, Yue Qin, Zuzanna Jablonska, Claudia I. Semprich, Lukas Mach, Monika Dabrowska, Nathan Richoz, Liam Bolt, Lira Mamanova, Rakeshlal Kapuge, Sam N. Barnett, Shani Perera, Carlos Talavera-López, Ilaria Mulas, Krishnaa T. Mahbubani, Liz Tuck, Lu Wang, Margaret M. Huang, Martin Prete, Sophie Pritchard, John Dark, Kourosh Saeb-Parsy, Minal Patel, Menna R. Clatworthy, Norbert Hübner, Rasheda A. Chowdhury, Michela Noseda & Sarah A. Teichmann
Nature 619, 801–810 (2023). https://doi.org/10.1038/s41586-023-06311-1
Publications
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About
CellTalk HHD is a large BBSRC-funded project focused on cellular communication in cardiac development.
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Research
World-leading research is at the heart of CellTalk HHD.
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Methods
We are passionate about developing and using the latest methods to explore the developing human heart.